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Paediatrics
Top Medical News
A 5-day course of oral amoxicillin-clavulanate performs just as wells as a 10-day course in the treatment of febrile urinary tract infection (fUTI) in children, a study has shown.
Babies born to mothers with type 1 diabetes (T1D) are at increased risk of congenital heart defects, as shown in a study.
Children with higher exposure to residential green spaces appear to have greater bone mineral density and a lower risk of having low bone density, as reported in a study.
Household food insecurity appears to be associated with the manifestation of externalizing and internalizing behaviour problems in young children in Singapore through both nutritional deficits and family stress, according to a study.
Wearable biosensors and machine learning algorithms show promise in predicting impending aggressive behaviour in youths with autism who are undergoing psychiatric treatment, offering opportunities for intervention and prevention.
Having greater serum folic acid levels and taking folic acid supplements more than once a week during the second and third trimesters appear to lower the risk of Kawasaki disease among infants, according to a study.
A single infusion of lovotibeglogene autotemcel (lovo-cel) resulted in near-complete resolution of vaso-occlusive events (VOEs) among patients with sickle cell disease (SCD), according to the combined analysis of phase I/II HGB-206 group C and phase III HGB-210 studies presented at ASH 2023.
Special Reports
Pegaspargase powder for solution for injection/infusion 3,750 units
Ustekinumab solution for injection (pre-filled syringe) 45 mg/0.5 mL and 90 mg/mL, and concentrate for solution for infusion (vial) 130 mg
Emulsion for infusion
Atypical haemolytic uraemic syndrome (aHUS) is a group of rare complement dysregulation disorders characterized by haemolytic anaemia, thrombocytopenia and acute kidney injury in both paediatric and adult patients. Prompt management is crucial to avoid life-threatening complications and invasive interventions. However, early detection and treatment remain challenging because aHUS is primarily diagnosed by exclusion. In an interview with MIMS Doctor, experts from Hong Kong shared current practices in the diagnosis and treatment of aHUS as well as their experience with using the complement component 5 (C5) inhibitor, eculizumab, for these patients.
As the most common type of chronic arthritis in children, juvenile idiopathic arthritis (JIA) can lead to long-term disability and requires precise management based on the particular JIA category. At a recent industry-sponsored webinar, Dr Nicolino Ruperto, paediatrician at the IRCCS Istituto Giannina Gaslini and senior scientist of the Paediatric Rheumatology International Trials Organisation (PRINTO, www.printo.it), Genova, Italy, shared updates in classification and management of JIA, including the latest clinical evidence from the phase III clinical trial of secukinumab, an anti–interleukin (IL)-17A.
Dupilumab solution for injection (pre-filled syringe) 200 mg/1.14 mL and 300 mg/2 mL
Dupilumab solution for injection (pre-filled syringe) 200 mg/1.14 mL and 300 mg/2 mL
Conference Reports
SARS-CoV-2 continues to evolve into newer variants. Post-Delta, these variants are generally more highly transmissible and immune-evasive, although not more virulent, said Dr Gregory Poland, Mary Lowell Leary Emeritus Professor of Medicine and director of Mayo Vaccine Research Group, Mayo Clinic in Rochester, Minnesota, US, at IDWeek 2023.
Podcast: Professor Flor Munoz discusses the importance of vaccination for pregnant women and children against COVID-19 at IDWeek 2023
Treatment with nirmatrelvir/ritonavir helps lower the incidence of post-COVID conditions (PCC) in older adults, according to a large study.
Treatment with single or multiple doses of ceftazidime-avibactam (CAZ-AVI) results in favourable clinical outcomes and is well tolerated in hospitalized neonates and young infants with suspected or confirmed bacterial infections, according to a phase IIa study presented at IDWeek 2023.
Bivalent COVID-19 vaccine conferred protection against SARS-COV-2 infection among children and adolescents aged 5–11 years, according to a recent study presented at IDWeek 2023.
Survivors of complicated monochorionic diamniotic (MCDA) twin pregnancies (ie, complicated twins) have a higher rate of adverse neurodevelopmental outcomes compared with uncomplicated twins, suggests a study presented at RCOG 2023.
The ileal bile acid transporter (IBAT) inhibitor maralixibat appears to quell itching and reduce serum bile acid concentration in children with progressive familial intrahepatic cholestasis (PFIC), while having a tolerable safety profile, according to data from the phase III MARCH-PFIC trial said to be the largest to date.
