HIGHLIGHT
Trelegy Ellipta

Trelegy Ellipta

Manufacturer:

GlaxoSmithKline

Distributor:

GlaxoSmithKline
Concise Prescribing Info
Contents
Per 100 mcg/62.5 mcg/25 mcg DPI Fluticasone furoate 100 mcg, umeclidinium Br 62.5 mcg, vilanterol trifenatate 25 mcg
Indications/Uses
Maintenance treatment to prevent & relieve symptoms associated w/ COPD.
Dosage/Direction for Use
Adult 1 inhalation once daily at the same time each day.
Contraindications
Hypersensitivity. Patients w/ severe milk-protein allergy.
Special Precautions
Not recommended in patients w/ asthma. Should not be used for the relief of acute symptoms ie, as rescue therapy for the treatment of acute episodes of bronchospasm. Paradoxical bronchospasm. Patients w/ unstable or life-threatening CV disease; pulmonary TB or chronic or untreated infections; narrow-angle glaucoma or urinary retention. Systemic corticosteroid effects may occur (high doses for long periods). Risk factors for pneumonia in patients w/ COPD eg, current smokers, patients w/ a history of prior to pneumonia, patients w/ low BMI & those w/ severe COPD. Monitor for systemic corticosteroid-related adverse reactions in patients w/ moderate to severe hepatic impairment. Pregnancy & lactation. Childn <18 yr.
Adverse Reactions
Nasopharyngitis. Pneumonia, URTI, bronchitis, pharyngitis, rhinitis, sinusitis, flu, mouth & throat candidiasis, UTI, viral resp tract infection; headache; couch, oropharyngeal pain, dysphonia; constipation, dry mouth; arthralgia, back pain.
Drug Interactions
May increase systemic exposure w/ CYP3A4 inhibitors (eg, ketoconazole, ritonavir). May potentiate the adverse reactions w/ other long-acting muscarinic antagonists or long-acting β2-adrenergic agonists. Vilanterol: May weaken or antagonise the effect w/ β-adrenergic blockers.
MIMS Class
Antiasthmatic & COPD Preparations
ATC Classification
R03AL08 - vilanterol, umeclidinium bromide and fluticasone furoate ; Belongs to the class of combination of adrenergics with anticholinergics, that may also include a corticosteroid. Used in the treatment of obstructive airway diseases.
Presentation/Packing
Form
Trelegy Ellipta 100/62.5/25 mcg DPI
Packing/Price
30 actuation x 1's
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